Official Journal of the American Academy of Pain Medicine, the Faculty of Pain Medicine of the Australian and New Zealand College of Anaesthetists and of the Spine Intervention Society

GENERAL SECTION Original Research Articles 628 Keren Reiner, PhD, Michal Granot, PhD, Eliran Soffer, MA, and Joshua Dan Lipsitz, PhD A Brief Mindfulness Meditation Training Increases Pain Threshold and Accelerates Modulation of Response to Tonic Pain in an Experimental Study The study examines effects of brief mindfulness meditation (MM) practice on pattern of change in response to tonic painful stimuli. The potential moderating role of dispositional mindfulness was also examined. Forty participants were randomly assigned to a brief MM training or control group. Compared to control, the MM group showed more rapid attenuation of pain intensity for tonic pain stimuli. Moderation analyses indicated that baseline mindfulness moderated effects of MM on pain threshold. 636 Cheng-ting Lee, MD, Trang T. Vo, BS, Abigail S. Cohen, BS, Shihab Ahmed, MD, Yi Zhang, MD, PhD, Jianren Mao, MD, PhD, and Lucy Chen, MD Profiles of Urine Drug Test in Clinical Pain Patients vs Pain Research Study Subjects This study shows that opioid therapy is commonly associated with positive urine drug testing in both clinical pain patients and subjects participating in pain research studies. Case Report 644 Jennifer Winegarden, DO, Daniel B. Carr, MD, and Ylisabyth S. Bradshaw, DO, MS Intravenous Ketamine for Rapid Opioid Dose Reduction, Reversal of Opioid-Induced Neurotoxicity, and Pain Control in Terminal Care: Case Report and Literature Review We report a case of opioid-induced neurotoxicity (OIN) in an actively dying hospice patient, its reversal and improved analgesia that followed opioid dosage reduction made possible after addition of IV ketamine. We review literature for diagnosis and treatment of OIN and suggest a mechanism of action for ketamine in neurotoxicity.